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VA Technical Reference Model v 24.4

Amazon Genomics Command Line Interface (CLI)
Amazon Genomics Command Line Interface (CLI) Technology

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Technologies must be operated and maintained in accordance with Federal and Department security and privacy policies and guidelines. More information on the proper use of the TRM can be found on the TRM Proper Use Tab/Section.

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Description: Amazon Genomics Command Line Interface (CLI) is an open source tool for genomics and life science users that automates the deployment of cloud infrastructure, providing the user with a command line interface to setup and run genomics workflows on Amazon Web Services (AWS) specified by languages like Workflow Description Language (WDL). Software developers and researchers can automatically provision, configure and scale cloud resources to enable faster and more cost-effective population-level genetics studies and drug discovery cycles.

This technology does not utilize a database. This technology creates the core infrastructure that Amazon Genomics CLI needs to operate, which includes a Dynamo Database (DynamoDB) table, a Simple Storage Service (S3) bucket and a Virtual Private Cloud (VPC). The DynamoDB table is used by the CLI for persistent state. The S3 bucket is used for durable workflow data and Amazon Genomics CLI metadata and the VPC is used to isolate compute resources.

The TRM decisions in this entry only apply to technologies and versions owned, operated, managed, patched, and version-controlled by VA. This includes technologies deployed as software installations on VMs within VA-controlled cloud environments (e.g. VA Enterprise Cloud (VAEC)). Cloud services provided by the VAEC, which are listed in the VAEC Service Catalog, and those controlled and managed by an external Cloud Service Provider (i.e. SaaS) are not in the purview of the TRM. For more information on the use of cloud services and cloud-based products within VA, including VA private clouds, please see the Enterprise Cloud Solutions Office (ECSO) Portal at:
Technology/Standard Usage Requirements: Users must ensure their use of this technology/standard is consistent with VA policies and standards, including, but not limited to, VA Handbooks 6102 and 6500; VA Directives 6004, 6513, and 6517; and National Institute of Standards and Technology (NIST) standards, including Federal Information Processing Standards (FIPS). Users must ensure sensitive data is properly protected in compliance with all VA regulations. Prior to use of this technology, users should check with their supervisor, Information Security Officer (ISO), Facility Chief Information Officer (CIO), or local Office of Information and Technology (OI&T) representative to ensure that all actions are consistent with current VA policies and procedures prior to implementation.
Section 508 Information: This technology has not been assessed by the Section 508 Office. The Implementer of this technology has the responsibility to ensure the version deployed is 508-compliant. Section 508 compliance may be reviewed by the Section 508 Office and appropriate remedial action required if necessary. For additional information or assistance regarding Section 508, please contact the Section 508 Office at
Decision: View Decisions

Decision Source: TRM Mgmt Group
Decision Process: One-VA TRM v23.9
Decision Date: 09/29/2023 at 18:28:12 UTC
Aliases: Genomics on Amazon Web Services (AWS)
Introduced By: TRM Request
Vendor Name: Amazon Web Services
- The information contained on this page is accurate as of the Decision Date (09/29/2023 at 18:28:12 UTC).