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VA Technical Reference Model v 24.7

Prime Technology

General InformationGeneral Information help

Technologies must be operated and maintained in accordance with Federal and Department security and privacy policies and guidelines. More information on the proper use of the TRM can be found on the TRM Proper Use Tab/Section.

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Description: Prime is a component of Schrodinger`s Biologics Suite. Prime is a protein structure prediction program that incorporates the complete protein structure prediction process from template identification, to alignment, to model building. Refinement can then be done from a separate set of panels, and includes side-chain prediction, loop prediction, binding-site refinement, and minimization. This software can also be used for prediction of the binding energy and strain energy of a set of ligands in a protein-ligand complex. The structural alignment utilities can be used to align two or more proteins so that the similar regions are aligned.

Prime does not utilize a database but requires the BioLuminate interface to run. This software stores data in the form of files, locally, on the user`s hard drive. If the underlying storage devices are encrypted, then by proxy all file data will be encrypted at the hardware level. No additional encryption is a part of any of Schrodinger`s file formats.

Please note, the support/technical documentation is only accessible by the account holder/purchaser of the technology, and is not readily available to users without an account on file with the vendor.
Technology/Standard Usage Requirements: Users must ensure their use of this technology/standard is consistent with VA policies and standards, including, but not limited to, VA Handbooks 6102 and 6500; VA Directives 6004, 6513, and 6517; and National Institute of Standards and Technology (NIST) standards, including Federal Information Processing Standards (FIPS). Users must ensure sensitive data is properly protected in compliance with all VA regulations. Prior to use of this technology, users should check with their supervisor, Information Security Officer (ISO), Facility Chief Information Officer (CIO), or local Office of Information and Technology (OI&T) representative to ensure that all actions are consistent with current VA policies and procedures prior to implementation.
Section 508 Information: This technology has been assessed by the Section 508 Office and found non-conformant. The Implementer of this technology has the responsibility to ensure the version deployed is 508-compliant. Section 508 compliance may be reviewed by the Section 508 Office and appropriate remedial action required if necessary. For additional information or assistance regarding Section 508, please contact the Section 508 Office at Please see reference tab for more information concerning product versions.
Decision: View Decisions

Decision Source: TRM Mgmt Group
Decision Process: One-VA TRM v23.3
Decision Date: 03/27/2023 at 15:43:21 UTC
Introduced By: TRM Request
Vendor Name: Schrodinger, LLC
- The information contained on this page is accurate as of the Decision Date (03/27/2023 at 15:43:21 UTC).